Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I
نویسندگان
چکیده
منابع مشابه
Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease†
Iron-sulfur (Fe-S) proteins contain prosthetic groups consisting of two or more iron atoms bridged by sulfur ligands, which facilitate multiple functions, including redox activity, enzymatic function, and maintenance of structural integrity. More than 20 proteins are involved in the biosynthesis of iron-sulfur clusters in eukaryotes. Defective Fe-S cluster synthesis not only affects activities ...
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Iron-sulfur (Fe-S) clusters are essential for numerous biological processes, including mitochondrial respiratory chain activity and various other enzymatic and regulatory functions. Human Fe-S cluster assembly proteins are frequently encoded by single genes, and inherited defects in some of these genes cause disease. Recently, the spectrum of diseases attributable to abnormal Fe-S cluster bioge...
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The cellular machinery that incorporates iron-sulfur clusters into proteins is directed to particular targets by adaptor proteins.
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MOLECULAR DETAILS OF THE MITOCHONDRIAL IRON SULFUR CLUSTERASSEMBLY PATHWAY bySWATI RAWATMay 2011Advisor: Dr. Timothy StemmlerMajor: Biochemistry and Molecular BiologyDegree: Doctor of PhilosophyIron-sulfur clusters are an important class of prosthetic group involved inelectron transfer, enzyme catalysis, and regulation of gene expression. Theirbiosynthesi...
متن کاملMössbauer Spectroscopy on Respiratory Complex I: The Iron–Sulfur Cluster Ensemble in the NADH-Reduced Enzyme Is Partially Oxidized
In mitochondria, complex I (NADH:quinone oxidoreductase) couples electron transfer to proton translocation across an energy-transducing membrane. It contains a flavin mononucleotide to oxidize NADH, and an unusually long series of iron-sulfur (FeS) clusters that transfer the electrons to quinone. Understanding electron transfer in complex I requires spectroscopic and structural data to be combi...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2009
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00817-09